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Selleck Chemicals
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Thermo Fisher
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Santa Cruz Biotechnology
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LGM Pharma
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Pragati Textile
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ICN Biomedicals
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Caraco Pharma
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Alpharma Inc
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Chemie GmbH
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Chemie GmbH
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AstraZeneca ltd
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Embiotic Laboratories
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Image Search Results
Journal: Pharmaceutics
Article Title: Drug Transport across Porcine Intestine Using an Ussing Chamber System: Regional Differences and the Effect of P-Glycoprotein and CYP3A4 Activity on Drug Absorption
doi: 10.3390/pharmaceutics11030139
Figure Lengend Snippet: The chemical structures and physicochemical properties of the drug molecules tested using the Ussing chamber system.
Article Snippet: Antipyrine, cimetidine, clotrimazole, N-desmethyl-tamoxifen hydrochloride, furosemide, hydrochlorothiazide, ketoprofen, maleic acid, (+/−)-metoprolol-(+)-tartrate, (+/−)-norverapamil hydrochloride, piroxicam, tamoxifen, terbutaline hemisulfate and (+/−)-verapamil hydrochloride 99% were purchased from Sigma-Aldrich (St. Louis, MO, USA); (+/−)-propranolol hydrochloride and
Techniques: Solubility
Journal: Pharmaceutics
Article Title: Drug Transport across Porcine Intestine Using an Ussing Chamber System: Regional Differences and the Effect of P-Glycoprotein and CYP3A4 Activity on Drug Absorption
doi: 10.3390/pharmaceutics11030139
Figure Lengend Snippet: The activity of the P-gp efflux transporter was confirmed by measuring P app,pig of the P-gp substrates, cimetidine and ranitidine (both prepared at a concentration of 100 µM in KBR), in the jejunum and the ileum in the presence (+VER; 100 µM) or absence (−VER) of verapamil (a P-gp inhibitor). Statistically significant differences (Student’s t-test) were observed for the ileum, which was consistent with the reports for humans in vivo. (Mean ± SD; n = number of replicates).
Article Snippet: Antipyrine, cimetidine, clotrimazole, N-desmethyl-tamoxifen hydrochloride, furosemide, hydrochlorothiazide, ketoprofen, maleic acid, (+/−)-metoprolol-(+)-tartrate, (+/−)-norverapamil hydrochloride, piroxicam, tamoxifen, terbutaline hemisulfate and (+/−)-verapamil hydrochloride 99% were purchased from Sigma-Aldrich (St. Louis, MO, USA); (+/−)-propranolol hydrochloride and
Techniques: Activity Assay, Concentration Assay, In Vivo
Journal: Pharmaceutics
Article Title: Drug Transport across Porcine Intestine Using an Ussing Chamber System: Regional Differences and the Effect of P-Glycoprotein and CYP3A4 Activity on Drug Absorption
doi: 10.3390/pharmaceutics11030139
Figure Lengend Snippet: The apparent drug permeability coefficients, P app,pig and Q DEP and Q PERM , in the jejunum and ileum for the drug substrates of the P-gp efflux transporter in the presence (+VER) and absence (−VER) of the P-gp inhibitor, verapamil.
Article Snippet: Antipyrine, cimetidine, clotrimazole, N-desmethyl-tamoxifen hydrochloride, furosemide, hydrochlorothiazide, ketoprofen, maleic acid, (+/−)-metoprolol-(+)-tartrate, (+/−)-norverapamil hydrochloride, piroxicam, tamoxifen, terbutaline hemisulfate and (+/−)-verapamil hydrochloride 99% were purchased from Sigma-Aldrich (St. Louis, MO, USA); (+/−)-propranolol hydrochloride and
Techniques: Permeability, Ex Vivo
Journal: Frontiers in immunology
Article Title: Histamine Regulates the Inflammatory Profile of SOD1-G93A Microglia and the Histaminergic System Is Dysregulated in Amyotrophic Lateral Sclerosis.
doi: 10.3389/fimmu.2017.01689
Figure Lengend Snippet: Figure 3 | MAPKs are activated by histamine in SOD1-G93A microglia. Wild-type (WT) and SOD1-G93A primary microglia were treated with histamine (100 µM) for 15 min–1 h–6 h and equal amounts of total lysates were subjected to SDS-PAGE, western blotting, and immunoreactions with anti-p-p38 and anti-p-38 (A) or with anti-pERK and anti-ERK (B). (C) SOD1-G93A microglia stimulated with histamine (100 µM) for 1 h in the presence of specific antagonists for H1R (orphenadrine, 10 µM), H2R (ranitidine, 10 µM), H3R (thioperamide, 5 µM), or H4R (JNJ-7777120, 5 µM) were subjected to immunoreactions with anti-pERK and anti-ERK. Anti-GAPDH was used for protein normalization. HA, histamine. Data represent mean ± SEM of n = 4 independent experiments. Statistical significance was calculated by ANOVA followed by Post Hoc Tukey’s test, as referred to ctrl cells, *p < 0.05 or to histamine-treated cells, #p < 0.05.
Article Snippet: JNJ7777120 was from Selleck Chemicals (USA), PD098059 from Calbiochem (USA),
Techniques: SDS Page, Western Blot
Journal: Journal of Young Pharmacists : JYP
Article Title: Development of a Floating Dosage Form of Ranitidine Hydrochloride by Statistical Optimization Technique
doi: 10.4103/0975-1483.71619
Figure Lengend Snippet: Composition of floating tablets of Ranitidine hydrochloride
Article Snippet:
Techniques:
Journal: Journal of Young Pharmacists : JYP
Article Title: Development of a Floating Dosage Form of Ranitidine Hydrochloride by Statistical Optimization Technique
doi: 10.4103/0975-1483.71619
Figure Lengend Snippet: Composition of the optimized formula
Article Snippet:
Techniques: